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Psychedelic Definition & Meaning Quantitative autoradiography revealed large increases in -labeled AA incorporation, particularly in the neocortex. The largest increases were seen in brain regions having high densities of 5-HT2A receptors, compared with 5-HT2C sites. Although there is very strong evidence that psychedelics act by an agonist or partial agonist action at 5-HT2A receptor, the past 15 years has seen increasing awareness of the fact that GPCRs can and do couple to more than one intracellular signaling pathway. MAOIs have been used to treat depression and are also a key ingredient in ayahuasca, the powerful Psychedelic brew native to indigenous cultures in South and Central America. A request for authorization from the Food and Drug Administration to administer an investigational drug or biological product to humans . This is the process through which companies obtain permission to initiate human clinical trials, and to facilitate interstate shipment of experimental